Taltobulin trifluoroacetate - MedChemExpress_企业动态_丁香通

来自 : www.biomart.cn/news/16/29838.. 发布时间：2021-03-24

简介 ：Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Catalog_No：HY-15584A Drug_Names：Taltobulin trifluoroacetate Alternative_Names：HTI-286 trifluoroacetate; SPA-110 trifluoroacetate 产品一级分类：信号通路 二级分类：生命科学试剂 

SMILES：CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\\C)C)=O.O=C(O)C(F)(F)F

Pathway：Cell Cycle/DNA Damage Target：Microtubule/Tubulin; ADC Cytotoxin; Apoptosis Research_Area：Cancer 国际站：Taltobulin trifluoroacetate
2021年3月11日Target:Microtubule/Tubulin; ADC Cytotoxin; Apoptosis Research_Area:Cancer 国际站:Taltobulin trifluoroacetate来源:MedChemExpress LLC 点击量:8...,企业动态,丁香通Taltobulin trifluoroacetate - MedChemExpress，Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) 是一种合成的三肽半胱氨酸类似物，Taltobulin 是一种有效的抗微管剂 (antimicrotubule)，可在体内外规避 P-糖蛋白介导的耐药性。Taltobulin trifluoroacetate 抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡 (apoptosis)。
Taltobulin trifluoroacetate